LEQSELVI (Deuruxolitinib) 8 mg Tablets: Uses, Dosage, Side Effects, and Complete Guide
Brand Name: LEQSELVI
Generic Name: Deuruxolitinib
Dosage Strength: 8 mg oral tablets
Approved by: U.S. FDA (2024) for treatment of severe alopecia areata in adults
What is LEQSELVI (Deuruxolitinib)?
LEQSELVI is a prescription medicine containing deuruxolitinib, an oral Janus kinase (JAK) inhibitor. It is approved for the treatment of severe alopecia areata, an autoimmune condition causing patchy or total hair loss. Deuruxolitinib works by targeting and blocking specific enzymes (JAK1/JAK2) that are involved in immune responses causing hair follicle destruction.
Key Highlights:
- Used in adults with severe alopecia areata
- First-of-its-kind oral JAK1/2 inhibitor approved for this condition
- Typically prescribed as 8 mg once or twice daily
- May show hair regrowth within 24 weeks
How LEQSELVI (Deuruxolitinib) Works?
LEQSELVI selectively inhibits JAK1 and JAK2 pathways, which are overactive in autoimmune conditions like alopecia areata. By blocking these pathways, deuruxolitinib helps reduce inflammation and immune attacks on hair follicles, allowing hair to regrow.
Mechanism of Action:
- Targets immune-related cytokines like IFN-γ and IL-15
- Interrupts the cycle of inflammation in hair follicles
- Promotes reactivation of dormant follicles
Indications – Who Should Use LEQSELVI?
LEQSELVI is indicated for adults suffering from:
- Severe alopecia areata (defined by >50% scalp hair loss)
- Patchy, total, or universal hair loss due to autoimmune cause
It is not currently recommended for children or pregnant women.
Dosage and Administration
Usual Adult Dose:
- 8 mg once or twice daily (based on severity and tolerance)
Administration: Take with or without food. Swallow whole with water.
Missed Dose:
If a dose is missed, take it as soon as remembered unless it’s near the time for the next dose. Do not double the dose.
Duration:
Visible hair regrowth may begin after 12–24 weeks of consistent use.
Side Effects of LEQSELVI
Common Side Effects:
- Headache
- Acne
- Fatigue
- Nausea
- Respiratory tract infections
Serious Side Effects:
- Increased risk of infections (TB, herpes zoster)
- Liver enzyme elevation
- Changes in blood counts
- Risk of thrombosis (rare)
Note: Regular blood monitoring is recommended during therapy.
Warnings and Precautions
- Do not use if you have active infection (e.g., TB, hepatitis)
- Consult a doctor if pregnant or planning pregnancy
- Avoid use with other immunosuppressive medications
- Monitor liver function and CBC regularly
Drug Interactions
LEQSELVI may interact with:
- Ketoconazole, Itraconazole (CYP3A4 inhibitors)
- Rifampin (CYP3A4 inducer)
- Immunosuppressants like methotrexate
Always inform your physician about all medicines you are taking.
Clinical Trials & Approval
LEQSELVI was evaluated in phase 3 clinical trials (e.g., THRIVE-AA1 and THRIVE-AA2), showing significant improvement in SALT scores (Severity of Alopecia Tool) after 24 weeks of use.
FDA Approval:
Approved in 2024 by the U.S. FDA after demonstration of efficacy and safety in patients with severe alopecia areata.
Storage & Handling
- Store below 25°C (77°F)
- Protect from moisture and sunlight
- Keep out of reach of children
Price and Availability in India
Currently, LEQSELVI may not be widely available in India. Once approved and launched in Indian markets, it may be priced on the higher side due to its novel mechanism and import costs. Generic alternatives might appear in future.
Hindi Section – LEQSELVI (Deuruxolitinib) 8 mg टैबलेट की जानकारी
LEQSELVI क्या है?
LEQSELVI (Deuruxolitinib) एक मौखिक टैबलेट है जो गंभीर एलोपेसिया एरीएटा (Alopecia Areata) के इलाज के लिए दी जाती है। यह एक प्रकार की ऑटोइम्यून बीमारी है जिसमें सिर और शरीर से बाल झड़ जाते हैं।
यह कैसे काम करता है?
Deuruxolitinib JAK1 और JAK2 एंजाइम को ब्लॉक करके इम्यून सिस्टम की ओवरएक्टिविटी को रोकता है, जिससे बालों की जड़ों में सूजन कम होती है और बाल वापस आने लगते हैं।
उपयोग:
- गंभीर हेयर लॉस (50% से ज्यादा)
- पैची, टोटल या यूनिवर्सल एलोपेसिया
डोज़ और सेवन विधि:
- 8 मिलीग्राम एक या दो बार रोजाना
- भोजन के साथ या बिना लिया जा सकता है
सावधानियाँ:
- इन्फेक्शन होने पर ना लें
- प्रेगनेंसी में डॉक्टर से सलाह लें
- लिवर टेस्ट और खून की जाँच नियमित कराएं
साइड इफेक्ट्स:
- सिरदर्द, मुँहासे, थकावट
- सांस की बीमारी, उल्टी
- संक्रमण का खतरा बढ़ सकता है
Conclusion
LEQSELVI (Deuruxolitinib) is a promising treatment for individuals struggling with severe alopecia areata. While it offers real hope for hair regrowth, it must be used under medical supervision due to its potential risks and side effects. Long-term studies and real-world data will continue to define its role in autoimmune dermatology.
Disclaimer: This blog is for informational purposes only. Please consult your doctor before starting any medication.
FAQs About LEQSELVI (Deuruxolitinib)
- Is LEQSELVI a permanent cure?
It helps regrow hair, but relapse may occur if treatment is stopped. - How long does it take to show results?
Visible improvement may be seen in 3–6 months. - Can I use it with Minoxidil?
Only if your dermatologist recommends combination therapy. - Is it available in India?
It may become available post-approval. Consult a dermatologist for alternatives.
Editor – www.saivanis.co.in
